Activity-Based vs. Purity-Based QC Metrics for Protein Synthesis Reagents
Measuring protein function, not just mass, reveals why reagent batches fail.
Senior Staff Writer
Miriam Osei-Bonsu spent eight years as a quality systems manager at a contract research organization before transitioning to science journalism, where she covers the regulatory and policy dimensions of reproducibility. Her reporting has focused on how institutional mandates translate—or fail to translate—into bench-level practice.
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Measuring protein function, not just mass, reveals why reagent batches fail.
Federal agencies now require researchers to share data and methods at publication, not months later.
NIH's enforcement system never verifies researchers actually followed reagent authentication rules.
Reagent opacity, not protocol flaws, blocks reproducible cell-free protein synthesis.
Vendor formulation secrecy undermines CFPS reproducibility.